Facebook Twiter Goole Plus Linked In YouTube Blogger

Pharmaceuticals

Pharmaceutical Pills Photo
Pharmaceutical Industry and Prescription Drug Warnings. Things you should definitely know about pharmaceutical drugs. Don't just treat the symptoms, you need to address the causes. Questions

Pharmacology

Previous SubjectNext Subject

The Marketing of Madness: Exposes the mistakes made by Psychiatrists and the Pharmaceutical industry (youtube 1 of 18).
Psychiatry: An Industry Of Death (youtube)
Ben Goldacre: Battling Bad Science (youtube)
American Addict (2013) 1:29
War on Health - Gary Null's Documentary Exposing the FDA (youtube)
Science Fraud: The Price for Fame and Fortune (youtube)
More Health Documentaries
Sleep Advertising

Disease Mongering is the practice of widening the diagnostic boundaries of illnesses and aggressively promoting their public awareness in order to expand the markets for treatment. Among the entities benefiting from selling and delivering treatments are pharmaceutical companies, physicians, and other professional or consumer organizations. (scumbag criminals)

Patient Care America are War Profiteers who make 18 million a day, from $42 million a month to more than $300 million. Tricare

Price Gouging is the same as Murder when a person dies because they could not afford the medicine they need to live.
Greedy drug company trying to gouge patients in need of Cancer Drugs
Good RX Check Prices for prescription drugs vary widely between pharmacies.

Now scumbags are using Orphan Drug Act of 1983 to charge high prices for needed drugs, while taking millions of dollars in government incentives and tax credits. When a drugmaker wins approval of a medicine for an orphan disease, the company gets seven years of exclusive rights to the marketplace, which means the FDA won't approve another version to treat that rare disease for seven years, even if the brand name company's patent has run out. By salami slicing the disease into subgroups, it allows them to get the orphan drug approval with all the government benefits and even some of the subsidies, to facilitate development of orphan drugs — drugs for rare diseases such as Huntington's Disease, myoclonus, ALS, Tourette syndrome and muscular dystrophy which affect small numbers of individuals residing in the United States.

Orphan Drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.

Rare Disease is a disease that affects a small percentage of the population. Estimated that more than 300 million people worldwide are living with one of the 7,000 diseases they define as "rare" orphan disease.

"Drug companies are not here to bring health to the population but to scam them on one level for vast amounts of money, by treating the symptoms and not addressing the cause." William Osler

H.R.6 - 21st Century Cures Act - 114th Congress House Bill

Doctor's Open Payments from Drug Companies - More Crimes

Doctors Oath

Reverse Settlement Payments or Pay to Delay are more criminal practices by the pharmaceutical industry where drug manufacturers pay competitors not to manufacture generic versions of their products, so drug manufacturers can continue to sell over priced drugs and steal millions from consumers and the elderly.

Almost six million prescriptions for some type of controlled substance were written last year alone in Connecticut. That’s almost double the amount of people who actually live here.
The amount of money the world spends on prescription drugs could rise to $1.5 trillion by 2021
There were 45 new drugs approved by the FDA last year and 41 in 2014. That's more than double the number that's been approved in 2016, which as of December 5 was just 19 new drugs. Homeopathic

Mayo Clinic Researchers say that nearly 70 percent of Americans are on at least one prescription drug, and more than half take two. The most commonly prescribed are antibiotics, antidepressants and painkilling opioids. Twenty percent of patients are on five or more prescription medications. Spending on prescription drugs reached $250 billion in 2009.
Survey found that 119 Million Americans over the age of 12 took prescription psychotherapeutic drugs. That's 45 percent of the population.

Poly Drug Use refers to the use of two or more psychoactive drugs in combination to achieve a particular effect. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low.

Polypharmacy is the use of four or more medications by a patient, generally adults aged over 65 years. Polypharmacy is most common in the elderly, affecting about 40% of older adults living in their own homes. About 21% of adults with intellectual disability are also exposed to polypharmacy.

Too Many Meds for the Elderly

Number Needed to Treat 

Deaths - Fraud Alerts

With Americans now filling four billion prescriptions a year, 59,000 children in the U.S. each year end up in the emergency room after accidental poisonings that involve taking medicine. In 48 percent of cases, kids got into their grandparents' medicines

Anxiety and Sleeping Pills 'Linked to Dementia'

Pharmaceutical Industry discovers, develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.

Pharmaceutical Compounding is the creation of a particular pharmaceutical product to fit the unique need of a patient. To do this, compounding pharmacists combine or process appropriate ingredients using various tools. This may be done for medically necessary reasons, such as to change the form of the medication from a solid pill to a liquid, to avoid a non-essential ingredient that the patient is allergic to, or to obtain the exact dose(s) needed or deemed best of particular active pharmaceutical ingredient(s).

Emergencies
1-800-222-1222
RX Dangers
Prescription Drugs Info
RX List

U.S. Companies Losing $10 Billion a Year Due to Workers' Opioid Abuse. And no one is getting arrested, just like the Bankers.

At least 100 people die from drug overdoses every day in the U.S. More than 36,000 people die from drug overdoses annually and most of these deaths are caused by prescription drugs. We have a serious problem when our treatments cause people to die, Asking for help shouldn't kill you, or put innocent people and family members in danger. The misuse and abuse of prescription painkillers was responsible for more than 475,000 emergency department visits in 2009, a number that nearly doubled in just five years. Today it is estimated that 100 million people in the U.S. suffer from chronic pain – more than the number with diabetes (26 million), heart disease (16 million) and cancer (12 million). Many who suffer from chronic pain will be treated with opioids. It is estimated that 5.1 million Americans abuse painkillers.
The Drug War is a Misguided Clusterfuck.

How did a war on drugs not include scumbag Doctors and criminal pharmaceutical companies when they clearly caused more deaths and more damage? The justice system is in on these crimes, accessories to murder. Another problem to solve.

Injury Prevention & Control: Prescription Drug Overdose
America’s Addiction to Opioids: Heroin and Prescription Drug Abuse

The risk for death when prescribed antipsychotics to control behavioral problems in demented patients (NPR)

IMS pharmaceutical market analysis firm, estimates the 2010 revenues for pharmaceuticals to be over $955 billion, and will exceed $1 trillion dollars by 2013. Big Pharma also shows revenues of around $300 billion in medical devices in 2012, and close to $320 billion in 2013. So the total revenues that Big Pharma will derive just from pharmaceuticals and devices will be around $1.32 trillion. According to the World Health Organization, estimated 2013 global revenues for vaccines is around $24 billion.

Antipsychotic
Psychotropic Medications
Psychopharmacology
Psychedelic Therapy
Mental Health Evaluation

Medical Prescription
Selective Serotonin Reuptake Inhibitor (SSRI)
Vaccines
Biosimilar
Generic Drug

Symptomatic Treatment
Pharmaceutical Industry
Pharmacology
Liaison Psychiatry
Worst Pills
Drug Dangers

Medicine Information
Medications Information
Archives of Internal Medicine
Pharmacopeial Convention 

Drug Errors
Chemistry
Too Many Meds Given to Senior Citizens
Annals of Internal Medicine

The Human Brain

Pharmaceutical Research
Is Greed ' the Biggest Killer in Healthcare?

Advancements: Pharmacotherapy is improving Personalized Medicine by Printing a Precision Dose of Medicine.

Atomwise Neural networks examine 3D images—thousands of molecules that might serve as drug candidates—and predict their
suitability for blocking the mechanism of a pathogen.

Novartis-MIT Center for Continuous Manufacturing

Knowing when to stop taking medications and preparing a person for the changes that they may experience when stopping meds.

Adherence to Treatment
Medication Adherence in Children
Non-compliance with Medical Treatment and Teens
 
Providing more information to the Patient and the Doctor will help make better choices and decisions.
Informulary

Low levels of the "happiness" neurotransmitter, serotonin.
Anti-depressants are are only fully effective roughly 30 percent of the time, and often come with troublesome side effects.
Elevated serotonin levels that are released and used by the brain during depressive episodes trigger processes that promote rumination -- the obsessive negative thinking that is the hallmark of Depression. Then, because they facilitate the production of serotonin, SSRI treatments exacerbate rumination and actually worsen symptoms of depression, especially at first. Over time, in some cases, the SSRIs can reverse ruminative processes and reduce symptoms -- but this is in spite of the medication, not because of it. As people and physicians become more aware that antidepressants only work for a limited period of time, and are less safe than they have been supposed, the use of antidepressant medications will decline and the use of Psychotherapies will increase.

Science Direct
Serotonin Theory of Depression (PDF)

Mental Health Failures
We need to improve and provide better mental health care services.


Research


Evidence-Based Medicine is an approach to medical practice intended to optimize decision-making by emphasizing the use of evidence from well-designed and -conducted Research.

Clinical Research is a branch of healthcare science that determines the safety and effectiveness (efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatment, diagnosis or for relieving symptoms of a disease. Clinical research is different from clinical practice. In clinical practice established treatments are used, while in clinical research evidence is collected to establish a treatment.

Drug Discovery is the process by which new candidate medications are discovered. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. In the past Drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice
to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.

You should always question Research Validated Programs
Experts?

Busting the billion-dollar myth: how to slash the cost of drug development

Science Research
Variables

Follow Up Study Lost to follow-up

Off-Label Use

Randomized Controlled Trial is a type of scientific (often medical) experiment which aims to reduce bias when testing a new treatment. The people participating in the trial are randomly allocated to either the group receiving the treatment under investigation or to a group receiving standard treatment (or placebo treatment) as the control. Randomization minimizes selection bias and the different comparison groups allow the researchers to determine any effects of the treatment when compared with the no treatment (control) group, while other variables are kept constant. The RCT is often considered the gold standard for a clinical trial. RCTs are often used to test the efficacy or effectiveness of various types of medical intervention and may provide information about adverse effects, such as drug reactions. Random assignment of intervention is done after subjects have been assessed for eligibility and recruited, but before the intervention to be studied begins.

Blind Experiment is an experiment in which information about the test is masked (kept) from the participant, to reduce or eliminate bias, until after a trial outcome is known. It is understood that bias may be intentional or unconscious, thus no dishonesty is implied by blinding. If both tester and subject are blinded, the trial is called a double-blind experiment.

Observational Study draws inferences from a sample to a population where the independent variable is not under the control of the researcher because of ethical concerns or logistical constraints. Observation Flaws

Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis.

Evidence

Clinical Trials Results Database
Clinical Trials
Clinical Trial are experiments done in clinical research.

A Replication Study involves repeating a study using the same methods but with different subjects and experimenters.

Replication Crisis refers to a methodological crisis in science in which scientists have found that the results of many scientific experiments are difficult or impossible to replicate on subsequent investigation, either by independent researchers or by the original researchers themselves. While the crisis has long-standing roots, the phrase was coined in the early 2010s as part of a growing awareness of the problem. 70% of them failed to reproduce another scientist's experiments (50% failed to reproduce their own experiment).

User-Fee Programs for Prescription Drugs (pdf)

Expanded Access, also known as compassionate use, refers to the use of an investigational new drug (IND) outside of a clinical trial by patients with serious or life-threatening conditions who do not meet the enrollment criteria for the clinical trial in progress
Compassionate Use (FDA)

Pre-Clinical Development
Scientific Control
Treatment and Control Groups
Clinical Research Associate 

"It seems that society is a control group for some crazy experiment"

United States Pharmacopeia

Peer Review

Systematic Review is a type of literature review that collects and critically analyzes multiple research studies or papers. A review of existing studies is often quicker and cheaper than embarking on a new study. Researchers use methods that are selected before one or more research questions are formulated, and then they aim to find and analyze studies that relate to and answer those questions. Systematic reviews of randomized controlled trials are key in the practice of evidence-based medicine
Science Collaboration

Propensity Score Matching is a statistical matching technique that attempts to estimate the effect of a treatment, policy, or other intervention by accounting for the covariates that predict receiving the treatment. PSM attempts to reduce the bias due to confounding variables that could be found in an estimate of the treatment effect obtained from simply comparing outcomes among units that received the treatment versus those that did not. Number Needed to Treat

Longitudinal Study is a correlational research study that involves repeated observations of the same variables over long periods of time, often many decades.

Epidemiology is the study and analysis of the patterns, causes, and effects of health and disease conditions in defined populations.

"Peer reviews are only as good as the peers. Peers have to be intelligent and free from bias in order for the feedback to work and to be accurate and effective."

Pathophysiology (Quantifiable Measurements)
Pathology  (Direct Observations)

Virtual Screening  is a computational technique used in drug discovery to search libraries of small molecules in order to identify those structures which are most likely to bind to a drug target, typically a protein receptor or enzyme.

Research Gate Make your research visible.

Lab Testing
Statistics
Problem Solving


Bias in Research


Bias in Research Studies

Publication Bias is a type of bias occurring in published academic research. It occurs when the outcome of an experiment or research study influences the decision whether to publish or otherwise distribute it. Publication bias is of interest because literature reviews of claims about support for a hypothesis or values for a parameter will themselves be biased if the original literature is contaminated by publication bias.

Selection Bias is the selection of individuals, groups or data for analysis in such a way that proper randomization is not achieved, thereby ensuring that the sample obtained is not representative of the population intended to be analyzed. It is sometimes referred to as the selection effect. The phrase "selection bias" most often refers to the distortion of a statistical analysis, resulting from the method of collecting samples. If the selection bias is not taken into account, then some conclusions of the study may not be accurate. Bias

Lead Time Bias is the length of time between the detection of a disease (usually based on new, experimental criteria) and
its usual clinical presentation and diagnosis (based on traditional criteria). It is the time between early diagnosis with screening and the time in which diagnosis would have been made without screening. It is an important factor when evaluating the effectiveness of a specific test.

Length Time Bias is a form of selection bias, a statistical distortion of results that can lead to incorrect conclusions about the data. Length time bias can occur when the lengths of intervals are analysed by selecting intervals that occupy randomly chosen points in time or space. That process favors longer intervals and so skews the data.

Scientific Misconduct is the violation of the standard codes of scholarly conduct and ethical behavior in professional scientific research.

But even with the research there is still a lot of corruption in the drug industry because of falsified research. More than two-thirds of biomedical papers Retracted over the past four decades were the result of misconduct, not error. More than 67 percent had to be retracted because of fraud, suspected fraud, fudged data, fraudulent studies, lying and duplicate publication or plagiarism.

Retraction
Retraction Watch
Scott Hensley
Significant Scientific Agreement

Second Opinion: Laetrile At Sloan-Kettering - by Eric Merola - Watch now free (vimeo)
Second Opinion
Assumptions
Validity

"It's sad knowing that criminals have manipulated research just for the money, which has caused the premature death of thousands of people, people who can have been saved if they had access to valuable information and knowledge, instead it was covered up and buried."
Patents


Results Of Many Clinical Trials Not Being Reported


Only 13 percent of scientists running clinical trials had reported their results.

Clinical Trials
Clinical Trials
Regulations
50% of Academic Papers are Never Read

Not All Trials are Published
Discontinuation and Nonpublication of Randomized Clinical Trials Conducted in Children

Sharing Clinical Trial Data
Sharing Clinical Trial Data (PDF)
Yale Open Data Access Project
Databases

Open Science is the movement to make scientific research, data and dissemination accessible to all levels of an inquiring society, amateur or professional. It encompasses practices such as publishing open research, campaigning for open access, encouraging scientists to practice open notebook science, and generally making it easier to publish and communicate scientific knowledge.

Open Science Data is a type of open data focused on publishing observations and results of scientific activities available for anyone to analyze and reuse.

Science Commons was a Creative Commons project for designing strategies and tools for faster, more efficient web-enabled scientific research. The organization's goals were to identify unnecessary barriers to research, craft policy guidelines and legal agreements to lower those barriers, and develop technology to make research data and materials easier to find and use. Its overarching goal was to speed the translation of data into discovery and thereby the value of research.

Web of Science is an online subscription-based scientific citation indexing service maintained by Thomson Reuters that provides a comprehensive citation search. It gives access to multiple databases that reference cross-disciplinary research, which allows for in-depth exploration of specialized sub-fields within an academic or scientific discipline.

Open Data
Open Source
Internet

Journal Impact Factors
Wok Info


When you hear people saying, "The Evidence Proves", or, "There Is No Evidence", or, "The Research Shows", these people are either lying or they are withholding key information and knowledge that keeps you from fully understanding the problem. So you have to ask, "What Evidence?" Where is this Evidence? What Research? Show Me! How was this Research Performed?
Who produced the Research? Most research creates more questions then it actually answers, or worse, it doesn't really apply to your particular problem. When you hear someone say "There's No Evidence", what they are actually saying is "I do not have enough information or knowledge to accurately understand this Problem". What is the exact Question?

Quack Watch
The National Council Against Health Fraud
Skepticism

Crazy People treating crazy people, now that's just crazy.

America and New Zealand are the only 2 developed countries in the world that allow Direct to Consumer Advertising of drugs.
So it's no surprise that 80% of all pharmaceutical drugs are consumed by Americans, and America is only 5% of the worlds population. Pharmaceutical companies also spend over 4 billion dollars on advertising these drugs to Americans, which the consumer pays for. So Americans are paying to be manipulated and drugged. So why are we the Ginny Pigs?

Media Literacy
Prescription Drug Alternatives


Mom Gets Rid of Food in her Kitchen that She Believes was Hurting her Family (youtube)
"Let Food Be Your Medicine and Medicine Be Your Food"
Nutrition


DSM


Diagnostic and Statistical Manual of Mental Disorders
or Drug Dealers Hand Book for short.

The DSM is a drug dealer’s training manual and nothing more. It is not science, it's only a drug pushers dream. Everyone has mental disorders if you look at all the so called symptoms that psychiatrists and doctors make up. Plus anyone can fake the symptoms, which leads to Overprescribing of Medications or just plain corrupted behavior. It's a felony to sell or use medications without prescriptions but somehow Doctors are rarely ever arrested. Only Science can fully understand what is happening to the human brain and how the brain is affected by foods, chemicals, environment and poor education. Then this information has to be passed on to parents, teachers and the general public. The FDA has failed to protect the general public from bogus pharmaceutical drugs and the claims they make. The FDA is corrupt and part of the drug dealing business. We should reevaluate the responsibilities of FDA and create a more responsible agency that is incorruptible and only serves the publics best interest and not the interests of money and corporations. Parents who believe that their child has ADD or ADHD should seek out Child Development Professionals instead of Doctors. The drugs that treat ADD or ADHD cause more damage to the person then actually helping them.

Worst Pills
Discount Generic Drugs 


Pharmaceutical Drugs in Public Drinking Water


A vast array of pharmaceuticals have been found in the drinking water supplies of at least 41 million Americans, including antibiotics, Anti-convulsants, Mood Stabilizers and Sex Hormones. (an Associated Press investigation).

Traces of Drugs in Drinking Water
Pharmaceuticals in Drinking Water (PDF)
Water Knowledge
EPA does not have any guidelines about pharmaceuticals in drinking water.
Endocrine Disruptor
Nanomedicine

About 90% of the drug is metabolized. Others aren’t Metabolized as much, and a lot of the parent compound is excreted. The undigested drugs and metabolites, the digested drugs, are either removed from the body as waste or sweat. These are either flushed down toilets are go down the drain in our showers.


Deaths and Over Doses from Prescription Drugs


The CDC said last month that prescription painkillers caused 15,000 U.S. deaths in 2008, more than triple the 4,000 deaths in 1999. Emergency room visits related to Hydrocodone abuse have shot from 19,221 in 2000 to 86,258 in 2009, according to the DEA. In Florida alone, hydrocodone caused 910 deaths and contributed to 1,803 others between 2003 and 2007. The U.S. consumes 99 percent of the world's hydrocodone and 83 percent of its Oxycodone, according to a 2008 study by the International Narcotics Control Board.

National Center for Biotechnology Information

About 48,000 women have died from painkiller overdoses between 1999 and 2010, an increase of 400 percent over the period.  In 2010, that amounted to about 18 women every day. For every woman who dies of a prescription painkiller overdose, 30 go to the emergency department for painkiller misuse or abuse. Although men are still more likely to die of prescription painkiller overdoses (more than 10,000 deaths in 2010), the gap between men and women is closing.  CDC

Adverse effects of medical treatment resulted in 142,000 deaths in 2013 up from 94,000 deaths in 1990 globally.

Disturbing new research says the number of U.S. babies born with signs of Opiate Drug Withdrawal has tripled in a decade because of a surge in pregnant women's use of legal and illegal narcotics, including Vicodin, OxyContin and Heroin.

The FDA shut down 1,677 illegal Pharmacy Websites in June 2013.  Another Drug War
So it's OK for legal Pharmacies to Kill?  Maybe Counterfeit Medications are Placebos?
The FBI say's Don't Put Your Health In the Hands of Crooks, but they don't say which crooks?
The National Association of Boards of Pharmacy recently performed an analysis of more than 10,000 websites, and found that 97% did not fully comply with state and federal regulations.   Pharmacy Verification Program
As of 2006, there were 58,768 Retail Pharmacies throughout the US. and way over 10,000 online pharmacies in the U.S.

The time, the people, the resources and the billions of dollars used to make pharmaceutical drugs are just Criminally Negligent and Totally Insane. It just goes to show you how incredibly ignorant people are and how horribly victimized the general public is. People are just Human Guinea Pigs for the greedy. If you were to use that same time, people, resources and money to stop polluting our drinking water and stop poisoning our foods, while at the same time improve education quality and quantity, you would have healthier people and a much healthier planet. Instead you have corrupt and irresponsible corporations making people drug addicts while at the same time polluting the earth, which in turn makes people sicker and even more dependent on drugs. A viscous and ignorant cycle. And these drugs have so many Side Effects that they not only contribute to more Birth Defects, they also create more diseases and more sickness that is actually being alleviated by the drugs themselves. Corporations don’t want to help you, Corporations don’t want to educate you, Corporations don’t even want to protect you, Corporations just want your money no matter whom they kill or whom they injure. Pharmaceutical drugs are an epidemic and a Weapon of Mass Destruction. I’m not saying all drugs are bad, just 90% of them. The most dangerous criminals are not behind bars; they are your Corporate Leaders and the Politicians they own that they Bought with our Money

Pharming Genetics
Alliance for Human Research Protection
Human Research Protections
Human Research
Human Experimentation
Unethical Human Experimentation in the United States


Pharmaceutical Drug Errors


5 million errors a year tied to wrong medications; some cause injury and death.
Confirm the spelling of the drug because 1,500 drugs have names so similar they’ve been confused with one or more other medications. U.S. outpatient pharmacies filled 3.9 billion 'Legal' prescriptions in 2009.  Patient Safety

A Child Experiences A Medication Error every 8 Minutes. Most of the medication errors involved liquid formulations. Errors were highest among children under the age of 1.

Institute for Safe Medication Practices
Drug Watch

Child-Resistant Packaging

Medical Errors kill around 195,000 Americans each year and costs the health care system as much as $300 billion annually.
So please ask about what Safety Guidelines and Procedures that your Hospital and Doctor follows and request a copy of the procedures and guidelines so that you can review them to better understand the decision making and so that you are more aware of your responsibilities and the responsibilities of the Doctor and Hospital. It is extremely important that you know what questions to ask. Number Needed to Treat

What really happens when you mix medications? (video and text)

An average of 195,000 people in the USA died due to potentially preventable, in-hospital medical errors in each of the years 2000, 2001 and 2002

Medical Misdiagnosis 
Patient Safety
Health Care Fraud and Abuse
Health Care Statistics
Hospital Connect Search
American Hospital Assoc
Solicitor Advice

Compliance describes the degree to which a patient correctly follows medical advice. Most commonly, it refers to medication or
drug compliance, but it can also apply to other situations such as medical device use, self care, self-directed exercises, or therapy sessions. Both the patient and the health-care provider affect compliance, and a positive physician-patient relationship is the most important factor in improving compliance, although the high cost of prescription medication also plays a major role.


Women and Men have differences when it comes to Medication amounts and types


Women's Health Research
Women's Health
Sex-Based Differences in Drug Activity
Status of Women Data
Sex and Gender-Based Analysis (SGBA)
Geo-Medicine
Big Data
Women's News
Scientists uncover a difference between the Sexes

Sex does matter: Key molecular process in brain is different in males and females.

Why medicine often has dangerous side effects for women (video)

International Center for Research on Women (ICRW)
UCLA Center for the Study of Women

Office of Minority Health Resource Center
He was one of a group of 14 researchers who found that diversity in biomedical research often does not reflect the American population.

Racial and Ethnic Minority Populations

Taking Race out of human genetics you can't make the genetic conclusions based on someone's race or ancestry. Subordination of different groups and social groupings based on myths about their biologic or genetic predispositions is not always accurate.

How Racism makes us Sick: David R. Williams (video and interactive text)

Looking at married couples who were together less than 20 years and couples together for more than 50, similarities were found between partners, like kidney function, total cholesterol levels, and the strength of their grips, which is a key predictor of mortality. Gerentological Society of America.


Racial Bias in Health Care


Differences in Physicians' Verbal and Nonverbal Communication With Black and White Patients at the End of Life
Racial Bias May Be Conveyed by Doctors’ Body Language
Patient Centered Communication
Patient-Centered Communication, Ratings of Care, and Concordance of Patient and Physician Race (PDF)
Differences between Racial and Ethnic groups in Health Care (PDF)
Cultural Diversity at the End of Life: Issues and Guidelines for Family Physicians
Heart disease is the leading cause of death for African Americans

African American Health Disparities Compared to Non-Hispanic Whites

Why genetic research must be more diverse, Keolu Fox: (video and interactive text)

 

Smart Drugs


There are many things that we have available that helps improve our Memory, like Exercise, Sleep, meditation, Breathing, Matcha Green Tea, Vitamins, Oils, Supplements, The Human Brain or just a Good Diet to name a few. So there are many alternatives that we have that we can research.

Modafinil is used for treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. It has also seen widespread off-label use as a purported cognition-enhancing agent.

Neural Oscillation
Synapse

GLYX-13 is an adjunctive therapy (therapy that uses more than one medication or modality for the treatment) of treatment-resistant major depressive disorder, which is a term used in clinical psychiatry to describe cases of major depressive disorder (MDD) that do not respond adequately to appropriate courses of at least two antidepressants.

Etherium Monotomic White Gold (amazon)

Khat is a flowering plant native to the Horn of Africa and the Arabian Peninsula. Among communities from these areas, khat chewing has a history as a social custom dating back thousands of years. Khat contains a monoamine alkaloid called cathinone, an amphetamine-like stimulant, which is said to cause excitement, loss of appetite and euphoria.

Donepezil is a medication used in the palliative treatment of Alzheimer's disease.

Transcranial Random Noise Stimulation (TRNS)

Nootropics are drugs, supplements, or other substances that improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. Cognitive Enhancer.

Brain Food
Intelligence
Study Skills
Learning Methods
Enhancing Cognition
Brain Maintenance
Placebo 

Healthy individuals run the risk of pushing themselves beyond optimal levels into hyperdopaminergic and hypernoradrenergic states, thus vitiating the very behaviors they are striving to improve. The brain doesn’t fully stop developing until age 25 or 30, making cognitive enhancement potentially risky even for users who are well into adulthood.

Adderall Abuse shows you just how incompetent our education system is. Kids who should be educated are not supposed to be ignorant about drugs. When students believe that they're getting an edge using drugs, that means they don't understand learning.  And if your using something that will help you pass a test, then you have already failed yourself, what happens after the test? I'm sure you would want to keep your good memory, so what will you be doing in your lifestyle that would help maintain your good memory? And on top of that you have to remember that most testing is flawed, It does not confirm you understand the knowledge, only that you studied enough to pass a particular test. And if the test itself is not even asking the right questions, then your knowledge becomes fragmented, irrelevant and ineffective. I hope you didn't pay for that, if you did, you got ripped off.

Taking drugs to be smarter?
This reminds me of that movie Limitless where Bradley Cooper in the end of the movie says something like.....
"If the drug makes you smarter then eventually you should become smart enough not to need the drug at all."
That of course implies that the person is learning the right things at the right time, because just having the ability to learn does not guarantee that you will learn the right things at the right time, thus you will still be ignorant. Our Schools are misleading the public, just like our Government.

"If you're not learning how ignorant you are, then you're not learning."

If someone has been taking Adderall for years to help them focus, that means that they have not been focusing on how not to need Adderall, or, focusing on why they would even need Adderall in the first place? Focus on that. What's the point of being interested in things if one of those things isn't you?

Be interested in yourself

Don't confuse personal perception for Reality

Just because something is boring to you, that doesn't mean that it's important or not important. And just because something is interesting to you, that doesn't mean that the thing is important or not important. What is stimulating to one person, may be dull to another. Like adrenaline junkies, fun for some, but not for others. 

Awareness

Understand the influences of hormones

Dopamine signal is a pleasure signal, it does not measure worth or importance. That is why you have a brain, which is to decide what's important and when it's important. I Like something, but not because dopamine tells me that I like it. Synesthesia
I would not call Dopamine a reward circuit, but more of an enhancing circuit of coincidence. When you have to do something that's important for your health, like eating certain vegetables that you don't like, your brain will not release dopamine, mostly because dopamine is not an indicator of right, wrong, good or bad. I believe that eventually people will learn how to release dopamine only when something they are doing is calculated to be right and good. So the dopamine could help encourage positive behavior and actions. But even then, awareness of our reality must not be compromised or degraded by hormones or by any other things such as chemicals, because we'll become more vulnerable to mistakes. You can't be a slave to feeling good, when feeling good makes you a slave.

Addictions
Plants that Reduce Cravings

Reasoning controls thinking, but reasoning is a skill that requires regular updates and practicing. And reasoning itself must be reasoned with, because if you are not reasoning the things that matter, then being able to reason will not matter.

Remember

Feeling bad is not bad, it is a personal feeling and an interpretation of a particular moment, feeling bad is not a measurement of reality. Feeling Sad is OK, Feeling Good is OK, and that time and place in Between is the Balance that we need, feeling aware and connected, and having a purpose, or a goal. Think positive, but not so positive that you positively stop thinking.



Citizen Science  -  DIY Chemistry


We should be thankful to ordinary people who have educated themselves enough in order to examine the world. Though we can't say that people experimenting on their own is more dangerous then the main stream pharmaceutical industry, but there are still many dangers. When we can all get together and share our notes, and share what we have learned, we won't waste so much time and resources, or kill lots of people unnecessarily. This is another reason why improving education is so important. We have learned a lot, now it's time to put what we have learned into practice.

What's In My Baggie? (youtube 1 hour)
What's in my baggie website
Britain's Illegal Rave Renaissance: LOCKED OFF (vice) (youtube 37 mins.)

Pill Testing is a process used to identify substances contained within a pill, usually illicit substances. With the increased prevalence of drugs being available in their pure forms, the terms "reagent testing" may also be used, with the reagents referred to in context simply as "reagent test kits".

Substance Test Kits
Ez Test Kits

Reagent Testing is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of formaldehyde and concentrated sulfuric acid, which is dripped onto the substance being tested.

Adulterant is a pejorative term for a substance found within other substances such as food, fuels or chemicals even though it is not allowed for legal or other reasons.
Adulterated drugs and devices (21 U.S. Code § 351)

Just because a drug is legal or pure does not mean that it's safe

Citizen Science is scientific research conducted, in whole or in part, by amateur or nonprofessional scientists. Citizen science is sometimes described as "public participation in scientific research", participatory monitoring and participatory action research.

Center for Open Science increase openness, integrity, and reproducibility of scholarly research.

DIY Science
DIY Biology

Australian Teens Recreate Key Ingredient in 'Pharma Bro' Drug for Just $20 A group of Australian teenagers have cheaply created the active ingredient in the drug Daraprim, which “Pharma Bro” Martin Shkreli hiked the cost of by 5,500 percent. Sydney Grammar students recreated 3.7 grams of Pyrimethamine, the active ingredient in the drug used to treat parasitic infection in patients with weakened immune systems.

The Deep Web Drug Lab

Designer Drugs is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests.

Mephedrone is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include drone,[5] M-CAT,[6] White Magic and meow meow. It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa. It comes in the form of tablets or a powder, which users can swallow, snort or inject, producing similar effects to MDMA, amphetamines and cocaine.

Legally High with Doctor Z (video)
Testing Legal Highs could Save Lives

Biopharmaceutical is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, they include vaccines, blood, blood components, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living cells used in cell therapy. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living cells or tissues. They (or their precursors or components) are isolated from living sources—human, animal, plant, fungal, or microbial.

Magic Mushrooms

Designer Drugs gives us more insight on how drugs can be customized towards the individual. But it shouldn't just be about getting high, it should be just enough of the drug to let the brain explore these new chemical compounds and explore the effects on the thinking pathways of the brain. Some drugs might reveal something beneficial, and other times reveal nothing beneficial at all. Drugs should be a temporary adjustment that reveals the persons own natural ability to feel good, and at the same time give the person a short period of time to analyze the world from a different perspective. Showing the person another way of thinking, maybe a more suitable way of processing the information, knowledge and experiences that they have accumulated in life. And once you have learned this, there should be no need for the drug, because now you can repeat the benefits of the drug yourself.  The drug should be just a way of showing you how. But most people can't understand this, another reason why improving education is so important.

"An undisciplined mind, along with the lack of knowledge, always leads to some form of abuse, whether sought or unsought."

"Designer drugs have promise, but we also have all kinds of natural drugs and herbs that we can examine and use."

Artificial Leaf as Mini-Factory for Medicine



Placebos  -  The Power of the Mind


Besides showing us how ineffective some drugs are, placebos has accidentally helped us to discover some of the powers of the human mind. From research scientists have found that Positivity and Hope is beneficial to the mind and the body because under those conditions the human body releases beneficial signaling molecules that travel all around the body. And depression and stress is not beneficial to the mind and the body because under those conditions the body does not release beneficial molecules. Hypochondriac

The placebo is symbolic to the powers of the human mind. So a deep breath can be your placebo or Laughing can be a placebo, a way to activate your harmonious state where ever you are, and also, to make yourself more aware of any unharmonious states that you could be experiencing, because the powers of the mind can also work against us. We still have a lot to learn.

Brain Plasticity

Patients who knowingly took placebos reported 30 percent less pain and 29 percent reduction in disability compared to control group.

Convincing yourself that you slept well tricks your brain into thinking that you did. It's called “Placebo Seep”.

Iceman Wim Hof is able to influence his autonomic nervous system and immune system at will.

Focus - Controls

Don't confuse the placebo effect with Having Confidence or having Willpower.

Can the human brain Imitate the Effects of a drug just by knowing how and why the drug works?
Smart Drugs

Why are Placebos sometimes more effective and safer then the actual drug?
Is the Power of the Mind being under estimated and under utilized?
Is Faith Healing just more proof that the Power of the Mind is real?
Is believing in Miracles prove that the power of the mind is real? 

Faith Healing is the ritualistic practice of prayer and gestures (such as laying on of hands) that are claimed to elicit divine intervention in spiritual and physical healing, especially the Christian practice. Believers assert that the healing of disease and disability can be brought about by religious faith through prayer and/or other rituals that, according to adherents, stimulate a divine presence and power. Belief in such divine intervention is derived from religious belief.
Miracle is an event not explicable by natural or scientific laws. Such an event may be attributed to a supernatural being (a deity), magic, a miracle worker, a saint or a religious leader. Coincidence

Psychosomatic Medicine is an interdisciplinary medical field exploring the relationships among social, psychological, and behavioral factors on bodily processes and quality of life in humans and animals. Some physical diseases are thought to be particularly prone to be made worse by mental factors such as stress and anxiety.

Biomedicine is a branch of medical science that applies biological and physiological principles to clinical practice. The branch especially applies to biology and physiology. Biomedicine also can relate to many other categories in health and biological related fields. It has been the dominant health system for more than a century.

Medicineless Hospital
Holistic

Placebo: Cracking the Code (youtube 12/9/2002) 
Lissa Rankin MD : Is There Scientific Proof We Can Heal Ourselves? at TEDxAmericanRiviera 2012 (video)
Natural Mystery: mind over body 1/3 (video)  investigations into the power of mind over the body. touches on many subjects including self healing (incl. cancer, heavy burns), hypnosis, kung fu, deep free diving, anesthetic free operations, mental exercise.

Placebo Effects of Caffeine on Cycling Performance
Scientists have identified for the first time the region in the brain responsible for the "placebo effect" in pain relief.

Latrogenesis refers to any effect on a person, resulting from any activity of one or more persons acting as healthcare professionals or promoting products or services as beneficial to health, that does not support a goal of the person affected.

Polywater was a hypothesized polymerized form of water that was the subject of much scientific controversy during the late 1960s. By 1969 the popular press had taken notice and sparked fears of a "polywater gap" in the USA.

Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Infections with toxoplasmosis usually cause no symptoms in adult humans. Occasionally there may be a few weeks or months of mild flu-like illness such as muscle aches and tender lymph nodes. In a small number of people, eye problems may develop. In those with a weak immune system, severe symptoms such as seizures and poor coordination may occur. If infected during pregnancy, a condition known as congenital toxoplasmosis may affect the child.

What's in a Placebo?

Drug companies manufacture their own placebos and they are not required to list the ingredients. An active placebo is one that is biologically active, rather than inert. Active placebos are designed to mimic the side-effects of drugs under study.

The Human Brain is a Chemical Warehouse, so we don't need more drugs, we need more education and more awareness.
Drugs manipulate the auto-pilot or natural functions of the brain, but drugs do not teach us how to manually control our brain, unless the drug was used to direct us towards a particular process, so that we can eventually learn how to control it on our own. 

Endocrine System
Hypothalamus - Thalamus
Peptide are biologically occurring short chains of amino acid monomers linked by peptide (amide) bonds.
Hormones
Emotions
Tiny Machines

Knowledge is a Placebo

When love hurts, a placebo can help Just believing you’re doing something to help yourself get over your ex can influence brain regions associated with emotional regulation and lessen the perception of pain.

Mind over Body

Our brains are at the top of the body to remind us of Mind over Matter. The mind must be the Hierarchy. The body effects the mind, so the mind must know the difference between what is happening in the body and what is happening in the brain. You don't want the body to control your thinking, but you don't want to ignore the body either. You have to accurately interpret the messages coming from your body, without having the messages effect your thinking ability, because then it will be almost impossible to know what is happening to your body, or to your mind. Our bodies and minds are sensitive because they have to be in order to sense changes that might be a danger to us. But because the mind is sensitive, we have to take extra care not to get confused between what's happening in the body and what's happening in the mind. It's usually the body, but if you don't understand the differences, then you will not be able to accurately analyze the true nature of what is happening in your body, or your mind.

Placebo is Latin for "I will please"

"Anything drugs can do I can do better; I can do anything better than drugs."

Could certain Miracles where people are mysteriously healed just be a placebo effect?

Placebo effect can also work against you, when you worry or when you believe that bad things will happen to you, your body will feel this stress in a negative way, and you will not benefit from your thinking.

People who have multiple personalities have diseases related to one personality but not the other personality. So one personality is fine, while the other personality suffers from a disease.

Nocebo is when a negative expectation of a phenomenon causes it to have a more negative effect than it otherwise would. A nocebo effect causes the perception that the phenomenon will have a negative outcome to actively influence the result. Mental states such as beliefs, expectations and anticipation can strongly influence the outcome of: disease; experience of pain; and even success of surgery. Positive expectations regarding a treatment can result in more positive outcomes and this effect is known as the placebo effect.

Pessimism
Worry
Anxiety

Losing Sleep

Sudden Unexpected Death Syndrome is sudden unexpected death of adolescents and adults, mainly during sleep. Sudden unexpected death syndrome is rare in most areas around the world.



The Thinker Man